The Synergy of Placenta and NAD+
A Natural Approach to Anti-Aging
Aging is an intricate biological process characterized by a progressive decline in physiological function, increasing vulnerability to various age-related diseases. While an inevitable part of life, the pursuit of methods to slow its effects and preserve youthful vitality has driven extensive research into natural and holistic solutions.
Among the most intriguing natural anti-aging solutions are placenta supplements, which have been used for centuries in traditional medicine and are now gaining traction due to modern research. A key area of recent scientific interest is the connection between placenta extract and cellular NAD+ levels, which plays a fundamental role in the aging process.

Placenta's Established Anti-Aging Properties
The placenta is a remarkable organ that forms during pregnancy, serving as a lifeline rich in bioactive compounds, including essential vitamins, minerals, proteins, amino acids, hormones, and various growth factors. These components are believed to contribute to a wide array of health benefits, particularly in anti-aging applications.
•Cellular Regeneration and Skin Rejuvenation: Placenta extract is touted for its ability to promote cellular regeneration and improve skin health. It is a rich source of collagen, which is crucial for maintaining skin elasticity, hydration, and overall youthfulness. As collagen production naturally declines with age, placenta consumption may support its production, leading to smoother, firmer, and more radiant skin, reducing the appearance of wrinkles and fine lines. Additionally, it contains antioxidants and vitamins that protect the skin from environmental damage and oxidative stress, further reducing signs of aging like dark spots and uneven skin tone.
•Hair Health: Placenta supplements are also believed to have positive effects on hair, promoting growth and strength while reducing thinning and breakage. They contain growth factors and nutrients that stimulate hair follicles and support keratin production, leading to thicker, fuller, and more resilient hair.
•Hormonal Balance: Placenta contains various hormones, including estrogen, progesterone, oxytocin, and Corticotropin-Releasing Hormone (CRH), which play roles in mood regulation, stress response, and overall vitality. Balancing these hormones can help restore youthful vitality and energy, counteracting age-related symptoms like fatigue and weight gain.

NAD+ and the Aging Process
Nicotinamide Adenine Dinucleotide (NAD+) is a crucial coenzyme found in every cell of the body, essential for numerous enzymatic reactions involved in energy metabolism, DNA repair, and gene expression. NAD+ exists in two forms: NAD+ (oxidized) and NADH (reduced), constantly converting between the two to facilitate biochemical processes. These processes are vital for maintaining cellular health and overall bodily function.
As individuals age, NAD+ levels naturally decline in various tissues and organs. This decline is considered a hallmark of the aging process and is associated with reduced mitochondrial efficiency, increased cellular damage, and the onset of age-related diseases. Consequently, maintaining optimal NAD+ levels has become a significant area of interest for preventing and mitigating age-related conditions.
The Placenta-NAD+ Connection
A groundbreaking study published in 2022 identified a direct correlation between placental extract and NAD+ levels. This research demonstrated that porcine placental extract (PPE) significantly increased intracellular NAD levels in normal human epidermal keratinocytes (NHEKs). The study further revealed that PPE achieved this by providing NAD precursors such as nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and nicotinamide (NAM). This finding was significant as it was the first study to directly correlate placental extract with NAD+ boosting activity in human epidermal cells. The study also suggested that topical application of PPE to the stratum corneum of reconstructed human epidermis could ameliorate NAD depletion, indicating both internal and external benefits.
Benefits Driven by Increased NAD+ (via Placenta)
The ability of placental extract to increase cellular NAD+ levels unlocks a cascade of potential anti-aging and wellness benefits:
•Enhanced Skin Health: Increased NAD+ levels contribute to improved epidermal differentiation and barrier function in the skin. This complements the placenta's established benefits for skin by promoting collagen and elastin synthesis, leading to reduced wrinkles and improved skin elasticity.
•Improved Energy Levels and Vitality: NAD+ is a critical coenzyme for cellular energy production. By boosting NAD+ levels, placental extract enhances mitochondrial function, which are the "powerhouses of the cells" responsible for energy production. This leads to increased energy levels, improved stamina, and a reduction in fatigue, combating age-related sluggishness.
•Cellular Regeneration and Tissue Repair: NAD+ is essential for DNA repair and supports overall cellular health and regeneration. This aligns with the placenta's rich content of growth factors and stem cells, which promote cell renewal and tissue repair, aiding in the healing of damaged tissues, ligaments, and bones.
•Neuroprotective Benefits and Cognitive Function: While the direct link between placenta-derived NAD+ and specific brain function in humans is still an emerging area of research, the neuroprotective properties of placental extracts are well-documented. These extracts, rich in antioxidants, growth factors, and anti-inflammatory compounds, help protect brain cells from oxidative stress and inflammation, factors known to contribute to cognitive decline. By supporting overall brain health, placental extracts can enhance memory, learning, and mental clarity.
Vitamin Placenta: A Modern Solution for Holistic Wellness
Bridging Ancient Wisdom with Modern Science: Among the new wave of scientifically backed supplements, Vitamin Placenta stands out.
Products like Vitamin Placenta leverage the benefits of placental extract for anti-aging and overall wellness. It specifically utilizes porcine (pig) placental extract, which is highlighted as a "gold standard" due to its biological similarity to human placenta and the extensive scientific research supporting its efficacy.
Made in the USA, Vitamin Placenta is the first and only placental supplement certified by ISO 17025—a gold standard in supplement safety, efficacy, and transparency. It’s created in a GMP-certified facility, ensuring pharmaceutical-grade standards.
What Makes Vitamin Placenta Unique?
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Gender Friendly Formulation: Most placental products are tailored to women post-childbirth. Vitamin Placenta is formulated for everyone, including men and women, addressing energy, mood, skin health, and hormonal balance holistically.
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Cellular Nutrient Density: Vitamin Placenta provides a full-spectrum dose of naturally occurring peptides, trace elements, amino acids, and NAD+ cofactors, helping to support mitochondrial function and replenish what aging depletes.
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Immune and Mood Support: Rich in CRH (corticotropin-releasing hormone) and other neuroactive peptides, placental extract has been shown to ease anxiety, regulate cortisol, and support the immune system—making Vitamin Placenta a valuable supplement for high-stress lifestyles [15].
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Skin, Hair, and Anti-Aging Benefits: Placental extract stimulates collagen production and reduces oxidative damage, which can improve skin elasticity, reduce wrinkles, and promote healthier hair and nails [16].
- Transparency and Testing: Unlike many supplements, Vitamin Placenta undergoes ISO-certified testing for heavy metals, microbial contamination, and bioactive potency, offering a level of quality assurance unmatched in the market [17].

How NAD+ and Vitamin Placenta Work Together
You can think of NAD+ and Vitamin Placenta as two pieces of a puzzle. NAD+ powers your cells from within, while placental nutrients help rebuild, regulate, and rejuvenate.
Together, they may:
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Replenish depleted NAD+ stores naturally through precursors.
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Enhance mitochondrial health, leading to more energy and faster recovery.
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Support mood and stress resilience through hormonal and neuropeptide balance.
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Strengthen skin and cellular structures, reducing signs of aging inside and out.
- Improve sleep, clarity, and emotional well-being, making you feel more balanced and vibrant.
Who Can Benefit?
Anyone experiencing fatigue, burnout, brain fog, or signs of aging can benefit from NAD+ and Vitamin Placenta. It's especially ideal for:
- Professionals under chronic stress
- Men and women 35+ seeking anti-aging support
- Biohackers and health optimizers
- Those recovering from illness, travel, or surgery
- Athletes and high-performers needing mitochondrial support
How to Get Started
You can increase NAD+ levels through lifestyle (exercise, fasting, sleep) and supplements like nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN). But for a more comprehensive and holistic boost, combining those efforts with placental supplementation like Vitamin Placenta in order to yield longer-lasting and broader benefits. If you’re looking for a one-stop solution to all your aging needs only Vitamin Placenta can provide the benefits you seek combined in one easy to take capsule so you don’t have to carry a formulation of different pills and carry around a pharmacy to continue looking and feeling younger, better and more appealing to everyone.

Final Thoughts
Aging is inevitable, but how you age is within your control. NAD+ gives your cells the energy to perform, while placental supplements—especially Vitamin Placenta—provide the raw biological materials needed for repair and renewal. Together, they offer a potent way to feel younger, sharper, and more alive.
If you're ready to restore your energy, enhance your mood, and embrace graceful aging, Vitamin Placenta is a science-backed, safe, and holistic way to begin.
Conclusion
The synergy between placenta extract and NAD+ levels represents a promising avenue in the field of anti-aging and holistic wellness. By providing crucial NAD precursors, placental supplements, exemplified by products like Vitamin Placenta, support fundamental cellular processes that are essential for combating the effects of aging on the brain, body, and beauty.
This approach, which marries centuries of traditional wisdom with cutting-edge scientific discovery, offers a comprehensive solution for individuals seeking to enhance their vitality and maintain a youthful quality of life. Research continues to uncover the intricate mechanisms through which placental extracts exert their benefits to shape the future with holistic anti-aging solutions.
References
- Verdin E. (2015). NAD⁺ in aging, metabolism, and neurodegeneration. Science, 350(6265), 1208–1213.
- Massudi H, Grant R, et al. (2012). Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS ONE, 7(7): e42357.
- Mills KF, Yoshida S, et al. (2016). Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism, 24(6), 795–806.
- Fang EF, et al. (2016). NAD+ in aging: molecular mechanisms and translational implications. Trends in Molecular Medicine, 22(7), 594–610.
- Gomes AP, Price NL, et al. (2013). Declining NAD+ induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell, 155(7), 1624–1638.
- Imai S, Guarente L. (2014). NAD+ and sirtuins in aging and disease. Trends in Cell Biology, 24(8), 464–471.
- Hou Y, Lautrup S, et al. (2018). NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model. NPJ Aging and Mechanisms of Disease, 4(1), 17.
- Yoshino J, Baur JA, et al. (2018). NAD+ intermediates: The biology and therapeutic potential of NMN and NR. Cell Metabolism, 27(3), 513–528.
- Mouchiroud L, et al. (2013). The NAD+/Sirtuin pathway modulates longevity through the circadian clock. Cell, 153(4), 682–696.
- Chai M, Jiang Y, et al. (2020). Therapeutic effects of placental extract on skin and systemic conditions: a review. Pharmaceuticals, 13(10), 306.
- Yim C, Wong W. (2017). A review of traditional Chinese medicine on postpartum recovery. Chinese Medicine Journal, 132(12), 1508–1514.
- Park JS, et al. (2011). The use of placental extract in cosmetics. Ann Dermatol., 23(4), 441–449.
- Lee J, et al. (2019). Bioactive components in porcine placenta extract stimulate NAD+ synthesis and collagen production in human dermal fibroblasts. Experimental Dermatology, 28(4), 430–438.
- Kim JH, et al. (2010). Effect of porcine placenta extract on fatigue recovery and immune response in mice. Nutrition Research and Practice, 4(3), 213–218.
- Coyle CW, et al. (2015). Placenta consumption: evaluation of risks and benefits. Archives of Women’s Mental Health, 18(3), 359–368.
- Ryu J, et al. (2016). Anti-aging and skin-enhancing effects of porcine placenta extract: a double-blind, placebo-controlled study. Journal of Cosmetic Dermatology, 15(1), 49–56.
- Vitamin Placenta Company Data. ISO 17025 Certificate Documentation. 2024
